AKAP7 Regulates CaM Kinase Activation in MCF‐7 Cells
نویسندگان
چکیده
منابع مشابه
Caspase activation in MCF7 cells responding to etoposide treatment.
Studies of the biochemical mechanisms evoked by conventional treatments for neoplastic diseases point to apoptosis as a key process for elimination of unwanted cells. Although the pathways through which chemotherapeutics promote cell death remain largely unknown, caspase proteases play a central role in the induction of apoptosis in response to a variety of stimuli including tumor necrosis fact...
متن کاملCaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology
Mitochondria are dynamic organelles that frequently move, divide, and fuse with one another to maintain their architecture and functions. However, the signaling mechanisms involved in these processes are still not well characterized. In this study, we analyze mitochondrial dynamics and morphology in neurons. Using time-lapse imaging, we find that Ca2+ influx through voltage-dependent Ca2+ chann...
متن کاملMatrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells.
RATIONALE Atherosclerosis is initiated by blood flow patterns that activate inflammatory pathways in endothelial cells. Activation of inflammatory signaling by fluid shear stress is highly dependent on the composition of the subendothelial extracellular matrix. The basement membrane proteins laminin and collagen found in normal vessels suppress flow-induced p21 activated kinase (PAK) and nuclea...
متن کاملDownregulation of N CaM kinase II in human tumor cells
Over two dozen alternative splice variants of CaMK-II, the type II Ca2/CaM-dependent protein kinase, are encoded from four genes (K, L, Q and N) in mammalian cells. Isozymes of K and L CaMK-II are well characterized in brain; however, an understanding of the relative endogenous levels of CaMK-II isozymes in a wide variety of non-neuronal cells has not yet been described. In this study, we have...
متن کاملAnticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.
AMP-activated protein kinase (AMPK) is a sensor of cellular energy status found in all eukaryotes. Recent studies indicate that AMPK activation strongly suppresses cell proliferation in tumor cells, which requires high rates of protein synthesis and de novo fatty acid synthesis for their rapid growth. Pomolic acid (PA) has been previously described as being active in inhibiting the growth of ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.1031.15